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It’s currently unclear whether or not the substitution was due to an injury.
The six-goal striker had recently been suffering from a cold.
He said earlier in the week on The Footballerâs Football Podcast: “I feel a little run down this week, so I need to make sure no illness kicks in fully, clear that out.”
Toon gaffer Eddie Howe said on his striker ahead of the game: “Yeah, I think heâs OK. Heâs had a little cold.
“Itâs funny how everything gets around, especially if you do a podcast! Finger crossed, heâll be OK.”
And England fans were left hoping Wilson was still just feeling the effects from the cold.
One wrote on Twitter: “Really hope @CallumWilson just still under the weather.”
Another said: “Callum Wilson off. Pray that’s because he isn’t feeling well.”
Three Lions boss Gareth Southgate was in the stands at St. Mary’s watching the game.
Wilson, who has two assists to go with his six goals this season, missed five games earlier this term with a hamstring injury.
The ex-Bournemouth forward is a strong candidate for a seat on the plane to Qatar, despite it being two years since his last England appearance.
There was also brief concern for Kieran Trippier, who is expected to be in Southgate’s squad.
He was treated by physios and had one hand on his hamstring just before the break, but thankfully for England and Newcastle, the right-back managed to play on.