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The last time the two sides played, Ireland demolished South Africa 38-3 in 2017.
And now the visitors will be looking for revenge as they face Ireland this weekend.
When is Ireland vs South Africa?
South Africa travel to Ireland on Saturday, 5 November.
The match is scheduled to get underway from 5:30pm UK time.
The Aviva Stadium will play host to the contest and is able to host up to 74,500 spectators.
What TV channel is it on and can I live stream it?
The clash will not be broadcast on terrestrial television, however you can still watch it.
Instead, it will be available to broadcast like on Amazon Prime.
The coverage is set to get underway from 5:00pm UK time.
What is the team news?
Ireland backs: Robert Baloucoune, Joey Carbery, Craig Casey, Ciaran Frawley, Jamison Gibson, Park Mack, Hansen, Robbie Henshaw, Hugo Keenan, Michael Lowry, Conor Murray, Stuart McCloskey, Calvin Nash, Jimmy O’Brien, Garry Ringrose, Johnny Sexton, Jacob Stockdale
Ireland forwards: Ryan Baird, Finlay Bealham, Tadhg Beirne, Jack Conan, Gavin Coombes, Caelan Doris, Tadhg Furlong, Dave Heffernan, Cian Healy, Rob Herring, Jeremy Loughman, Joe McCarthy, Peter O’Mahony, Tom O’Toole, Andrew Porter, Cian Prendergast, James Ryan, Dan Sheehan, Nick Timoney, Kieran Treadwell, Josh van der Flier
South Africa backs: Kurt-Lee Arendse, Damian de Allende, Faf de Klerk, Andre Esterhuizen, Sacha Feinberg-Mngomezulu, Jaden Hendrikse, Cheslin Kolbe, Jesse Kriel, Wille le Roux, Manie Libbok, Makazole Mapimpi, Cobus Reinach, Damian Willemse
South Africa forwards: Lood de Jager, Pieter-Steph du Toit, Thomas du Toit, Even Etzebeth, Deon Fourie, Jason Jenkins, Steven Kitshoff, Sita Kolisi, Vincent Koch, Frans Malherbe, Malcolm Marx, Bongi Mbonambi, Salmaan Moerat, Franco Mostert, Ox Nche, Trevor Nyakane, Marvin Orie, Evan Roos, Kwagga Smith, Jasper Wiese
Latest Odds
Ireland to win – 8/15
Draw – 17/1
South Africa – 7/4
*Odds courtesy of Betfair are correct at time of publication